Brain atrophy at onset and physical disability in multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Brain atrophy at onset and physical disability in multiple sclerosis.
UNLABELLED The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categor...
متن کاملImpairment, disability and fatigue in multiple sclerosis
Background: Identifying the predictors of pain is important for both health professionals and researchers, because pain has repeatedly been found to be a strong predictor of activity limitations and participation restrictions. The objective of this study was to determine the predictors of pain presence and severity in a large, well-designed sample of community dwelling individuals with multip...
متن کاملRetinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis.
BACKGROUND Studying axonal loss in the retina is a promising biomarker for multiple sclerosis (MS). Our aim was to compare optical coherence tomography (OCT) and Heidelberg retinal tomography (HRT) techniques to measure the thickness of the retinal nerve fiber layer (RNFL) in patients with MS, and to explore the relationship between changes in the RNFL thickness with physical and cognitive disa...
متن کاملRevisiting Brain Atrophy and Its Relationship to Disability in Multiple Sclerosis
BACKGROUND Brain atrophy is a well-accepted imaging biomarker of multiple sclerosis (MS) that partially correlates with both physical disability and cognitive impairment. METHODOLOGY/PRINCIPAL FINDINGS Based on MRI scans of 60 MS cases and 37 healthy volunteers, we measured the volumes of white matter (WM) lesions, cortical gray matter (GM), cerebral WM, caudate nucleus, putamen, thalamus, ve...
متن کاملBrain atrophy and disability progression in multiple sclerosis patients: a 10-year follow-up study.
OBJECTIVES To identify MRI biomarkers associated with long-term disability progression in patients with multiple sclerosis (MS), and to define the rate of evolution of global, tissue-specific and regional atrophy in patients with MS over long-term. METHODS MRI of the brain and clinical neurological assessment was performed in 81 patients at time of first visit and after 5 and 10 years of foll...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arquivos de Neuro-Psiquiatria
سال: 2012
ISSN: 0004-282X
DOI: 10.1590/s0004-282x2012001000003